By Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)
The present explosion of latest parts of controversy within the remedy of acute lymphocytic leukemia in adults and teens makes this entire ebook a miles wanted reference for hematologists and oncologists. This booklet assembles best gurus from around the world to hide the whole spectrum of ALL subtypes and their remedies. particular subject matters of dialogue contain symptoms for allogeneic bone marrow transplant in first whole remission, the position of minimum residual illness in making remedy judgements, the remedy of teens, and the remedy of Philadelphia chromosome confident ALL with the appearance of the tyrosine kinase inhibitors. this is often the 1st e-book to concentration solely at the grownup ALL sufferer. It offers an entire review of prognosis, molecular pathogenesis, evaluate, and therapy for this crucial sufferer population.
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Additional resources for Adult Acute Lymphocytic Leukemia: Biology and Treatment
Prognostic and oncogenic relevance of TLX1/HOX11 expression level in T-ALLs. Blood, 110(7), 2324–2330. 56. Ferrando, A. , et al. (2004). Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet, 363(9408), 535–536. 57. , et al. (2008). Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: Experience of the German multicenter ALL study group. Leukemia, 22(6), 1154–1160.
The lymphoblasts in B-ALL are almost always positive for the B-cell markers: CD19, cytoplasmic CD79a, and cytoplasmic CD22. None of these markers by itself are specific for B-lineage leukemia, but their expression on the lymphoblasts in combination strongly supports the diagnosis. CD20 is specific for B-lineage, but is often dimly expressed or negative in B-ALL. CD79a and PAX5 are the most frequently utilized antibodies to document B-cell differentiation in tissue sections; however, they are not specific.
3–35). Some translocations result in a creation of fusion genes, such as PICALM-MLLT10 t(10;11) (p13;q14) and MLL-ENL t(11;19) (q23;p13) . Activating mutations in the NOTCH1 gene, important for T cell development, are detected in 50% of adult T-ALL patients and are associated with a shorter survival [64, 65]. 2 Acute Lymphocytic Leukemia – Clinical Features and Making the Diagnosis 19 In some cases translocations not detected by routine karyotyping can be identified by molecular genetic studies.
Adult Acute Lymphocytic Leukemia: Biology and Treatment by Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)